phenobarbital sodium molecular weight - An Overview
phenobarbital sodium molecular weight - An Overview
Blog Article
pentobarbital will lower the extent or effect of buprenorphine, extended-acting injection by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Carefully. Individuals who transfer to buprenorphine extensive-acting injection from transmucosal buprenorphine coadministered with CYP3A4 inducers should be monitored to be certain buprenorphine plasma degrees are satisfactory.
DESCRIPTION The barbiturates are nonselective central anxious program depressants which are largely used as sedative hypnotics and also anticonvulsants in subhypnotic doses. The barbiturates and their sodium salts are matter to manage underneath the Federal Controlled Substances Act (See “Drug Abuse and Dependence” portion). The sodium salts of amobarbital, pentobarbital, phenobarbital, and secobarbital are available as sterile parenteral solutions. Barbiturates are substituted pyrimidine derivatives where the basic structure common to these drugs is barbituric acid, a substance which has no central nervous program (CNS) action.
pentobarbital will reduce the level or effect of triazolam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.
pentobarbital will minimize the extent or effect of prednisone by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.
Phenytoin, sodium valproate, valproic acid: The effect of barbiturates around the metabolism of phenytoin seems to be variable. Some investigators report an accelerating effect, while others report no effect. As the effect of barbiturates within the metabolism of phenytoin is not really predictable, phenytoin and barbiturate blood ranges ought to be monitored much more often if these drugs are given concurrently.
pentobarbital will decrease the extent or effect of ramelteon by influencing hepatic enzyme CYP2C9/10 metabolism. Minimal/Significance Not known.
Distinctive client inhabitants: Dosage really should be lowered in the elderly or debilitated because these people may be much more sensitive to barbiturates. Dosage ought to be decreased for patients with impaired renal function or hepatic sickness.
pentobarbital will decrease the level or effect of sufentanil by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Unknown.
pentobarbital will minimize the extent or effect of netupitant/palonosetron by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. Netupitant is especially metabolized by CYP3A4; keep away website from use in clients who will be chronically making use of a solid CYP3A4 inducer
pentobarbital will minimize the extent or effect of solifenacin by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.
pentobarbital will lessen the level or effect of irinotecan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor.
The effect with the resultant diminished blood levels of griseofulvin on therapeutic reaction hasn't been established. Having said that, It will be preferable to stay away from concomitant administration of such drugs.
Nevertheless, using barbiturates as sedatives inside the postoperative surgical interval and as adjuncts to cancer chemotherapy is properly established.
pentobarbital decreases amounts of panobinostat by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Powerful CYP3A4 inducers can decrease panobinostat amounts by ~70% and produce remedy failure.